Advantus Large Dog Soft Chews, 37.5 Mg. are a fast-acting dog flea treatment of flea infestations. Advantus flea treatment for dogs starts killing fleas within 1 hour with just a single dose. In the event of continued infestation, you can safely repeat treatment as often as once per day. These flavored soft chews are for dogs and puppies 10 weeks of age and older. Warning: Not for human use. Keep this and all drugs out of the reach of children and pets.